DEVELOPMENT AND OPTIMIZATION OF ASTRAGALIN-LOADED POLYMERIC NANOPARTICLES USING CENTRAL COMPOSITE FACTORIAL DESIGN
نویسندگان
چکیده
Objective: The objective of the present study was to develop and optimize Astragalin-loaded polymeric nanoparticles (AST-NPs) using a central composite factorial design (CCD). Methods: AST-NPs were prepared by dialysis method. CCD employed influence formulation factors, polymer concentration, aqueous organic phase ratio, process parameter stirring time on dependent physicochemical characteristics, particle size, zeta potential, percentage entrapment efficiency (%EE) drugs. optimized evaluated for in vitro release studies subjected stability studies. Results: Polymer concentration parameters produce with desired parameters. NPs characterized Fourier transmission infrared (FT-IR), differential scanning calorimetry (DSC), drug loading, efficiency, FT-IR DSC indicated that there no interaction between polymer. exhibits stability. Optimized exhibited spherical porous surfaces mean PS 118 nm, potential of-25 mV, %EE 89%. Conclusion: composition
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ژورنال
عنوان ژورنال: International Journal of Applied Pharmaceutics
سال: 2022
ISSN: ['0975-7058']
DOI: https://doi.org/10.22159/ijap.2022v14i5.44315